Process for the manufacture of 3-halogeno-5-hydroxy-tricyclo{8 2.2.1.0{hu 2.6{b {9 heptanes

ABSTRACT

New process for the production of 3-halogen-5-hydroxytricyclo(2.2.1.02.6)heptanes is disclosed by which said heptanes can be obtained in a pure form and with high yields.

United States Patent Huff Dec. 2, 1975 PROCESS FOR THE MANUFACTURE OF 3-HALOGENO-5-HYDROXY- TRICYCLO[2.2.1.01HEPTANES Inventor: Roger K. Huff, Wokingham,

England Assignee: Ciba-Geigy Corporation, Ardsley,

Filed: May 11, 1973 Appl. N0.: 359,585

Foreign Application Priority Data July 3, I972 Switzerland 992l/72 US. Cl. 260/617 F Int. Cl. C07C 35/22 Field of Search 260/617 F References Cited FOREIGN PATENTS OR APPLICATIONS l0/1954 United Kingdom 260/6l7 F OTHER PUBLICATIONS Wagner and Zook, Synthetic Org. Chem. p. 109. Wiley, N.Y., N.Y. (1953).

Djerarsi, Chem. Rev.," Vol. 43, pp. 27l and 272. (I948).

Ziegler, Justus Liebigs Annalen der Chemie". Vol. 5l, pp. 80-119, (1942).

Primary Examiner-Paul M. Coughlan. Jr. Assistant Examiner-D. B. Springer Attorney. Agent, or Firm-Luther A. R. Hall [57] ABSTRACT 2 Claims, No Drawings PROCESS FOR TH MANUFACTURE or 3-HALOGENQ-5rHYDROXY- TRICYCLO[2.2.1.0.]HEPTANES No. 717,010, yields highproportions of by-products which are difficult to separate off, especially of an unsaturated isomer, alongside the desired 3-halogeno-5- hydroxy-tricyclo[2.2.1.0]heptane.

It has now been found that 3-halogeno-5-hydroxytricyclo[2.2.1.01heptanes of the formula Hal wherein Hal represents chlorine or bromine can, surprisingly, be prepared in a pure form and with very good yields by reacting bicyclo[2.2.1]hepta-2,5-diene of the formula 11 with a N-halogenosuccinimide of the formula 111 (III) N-Hal wherein Hal has the meaning indicated under the formula I, in an aqueous medium.

Preferably, a N-halogenosuccinimide of the formula III, in which Hal represents chlorine, is used in the process according to the invention.

The reaction is advantageously carried out in a mixture of water and a water-miscible organic solvent which is inert under the reaction conditions. Examples of suitable solvents are aliphatic or cycloaliphatic ketones, cyclic ethers or double-sided ethers of mono ethylene glycol, diethylene glycol and triethylene glycol, such as acetone, methyl ethyl ketone, cyclopentanone, cyclohexanone, dioxane, tetrahydrofurane, tetrahydropyrane, ethylene glycol dimethyl ether, ethylene glycol diethyl ether, diethylene glycol dibutyl ether and triethylene glycol dimethyl ether.

The reaction temperatures are appropriately between about 0C and C.

The succinimicle liberated during the reaction can be recovered practically quantitativelyand can be recycled to the process after halogenation at the nitrogen atom. V

The 3-halogeno-5-hydroxy-tricyclo[ 2.2. l .0"""]heptanes obtained according to the invention can be isolated and purified in the usual manner. for example by extraction with a suitable solvent, such as pcntane, hexane or diethyl ether, and subsequent distillation. They are obtained in the form of pale yellowish oils and can, for example, be used as intermediate products for the manufacture of pharmaceutical or agricultural active substances, such as insecticides or fungicides, or directly or as starting materials in the synthesis of high boiling stable liquids and plasticisers [compare British Patent Specification No. 717,010].

EXAMPLE 1 G1 on 20 g of bicyc1o[2.2.l]hepta-2,5-diene are suspended, with vigorous stirring, in a mixture of 100 ml of dioxane or acetone and 100 ml of water. After cooling the resulting suspension to about 25C 29 g of N-chlorosuccinimide are slowly added in portions. The reaction mixture is kept at this temperature for 2 hours and is subsequently diluted with approx. 200 ml of water, after which the reaction product is extracted three times with 100 ml of diethyl ether at a time. The ether solution is washed with water and dried over magnesium sulphate and the solvent is removed under reduced pressure.

After distillation of the residue, 22 g of theory) of 3-chloro-5-hydroxy-tricyclo[2.2.l.O Jheptane are obtained in the form of a slightly yellowish oil; boiling point 5658C/0.01 mm Hg; chlorine content: calculated 11.06%; found 11.13%

IR spectrum (CHCl 3.560, 3,390, 1,290, 1,070,

956, 936, 908, 874, 825 and 810 cm. NMR spectrum (CDCI 6=trans 4.46 (t,lH), 3.96 (t,111), 1.0-1.8 (m,6H)

ppm, cis 3.84 (t,lH), 3.78 (t,1H), 1.0-1.8 (m,6H) ppm.

EXAMPLE2 If, in Example 1, 39 g of N-bromosuccinimide are used instead of 29 g of N-chlorosuccinimide, otherwise employing the same procedure, working up the reaction product as described in Example 1 yields 24 g (60% of theory) of 3-bromo-5-hydroxy-tricyclo[2.2.l.0 ']heptane; boiling point 73-76C/0.01 mm Hg; bromine content: calculated 42.26%; found 44.64%.

3 IR spectrum (CHCI 3,600, 3.450. L310, L285. 1.165. L070. 1,045. L030. 932. 872. 822 and 810 cml. NMR spectrum (CDCl;,):

6 trans 4.56 (t,lH). 3.99 (Ll H). 3.96 (L1H).

3.90 (t,lH), cis l.22.2 (m.6H) ppm. What I claim is: 1. An improved process for the manufacture of 3- halogen-S-hydrox '-tricyclol2.2.l.0 "]heptanes of the formula.

Hal

where Hal represents chlorine or bromine wherein hicyclolll l ]hepta-2.5-diene is reacted with hypohalous acid or a reagent forming a hypohalous acid in an aqueous organic medium at 0 to 30C temperature and the product is isolated by extraction and distillation wherein the improvement comprises employing. based on bic \'clo[2.2.l]hepta-2,5-diene,

essentially an equimolar amount of N-chlorosuccinimide or N-bromosuccinimide as said reagent forming a hypohalous acid, and carrying out the reaction in said aqueous organic medium consisting of a 50:50 by volume of mixture of water: dioxane or water: acetone. 2. The process of claim 1 wherein the N- halogenosuccinimide is N-chlorosuccinimide.

l l =l= 

1. AN IMPROVED PROCESS FOR THE MANUFACTURE OF 3-HALOGEN5-HYDROXY-TRICYCLOL(2.2.1.0**2.6)HEPTANES OF THE FORMULA:
 2. The process of claim 1 wherein the N-halogenosuccinimide is N-chlorosuccinimide. 